Postdoc in the chemistry of oat-Fusarium interactions

Job title: Postdoc in the chemistry of oat-Fusarium interactions

Company: Københavns Universitet


Job description: The Department of Plant and Environmental Sciences, Section for Plant Biochemistry offers a two-year postdoc position to investigate the chemistry of the interaction between oat and the fungal pathogen Fusarium spp., starting 1 May 2025 or as soon as possible thereafter.The postdoc’s duties will include research within plant biochemistry, enzymology, molecular biology, analytical chemistry and plant pathogen defense reactions as well as teaching. The post may also include performance of other duties.Description of the scientific research environmentThe Department of Plant and Environmental Sciences is a large department (400 employees) dedicated to plant, microbial, and environmental sciences ( ). Further information on the Department is linked at .The postdoctoral position is funded by a five-year research grant from the Novo Nordisk Foundation that investigates plant strategies for detoxification of mycotoxins in the oat-Fusarium interaction, with a main focus on glutathione transferase enzymes (GSTs). The successful applicant will join the Plant Metabolic Plasticity research group, headed by Associate Professor Nanna Bjarnholt and embedded in the Section for Plant Biochemistry. The project is carried out in collaboration with plant pathologists Professor David Collinge and Associate Professor Birgit Jensen in the Section for Microbial Ecology and Biotechnology.The Section for Plant Biochemistry is among World leading laboratories within plant biochemistry and biotechnology. The section hosts seven research groups that mainly work with the biochemistry, physiology, ecology and biotechnology of plant specialized metabolism. We also host and collaborate about maintaining a metabolomics platform with several state-of-the-art instruments for GC- and LC-MS analyses, and more recently a facility for Mass Spectrometry Imaging of plant tissues, headed by the PI of this advertised postdoc position. The Section is characterized by a highly interactive, supportive and international research environment, interdisciplinary science, and a strong national and international network ( ).Description of project and candidateGlobal food security is challenged by fungal diseases annually devastating a third of all crops. Key staple food cereal crops are strongly affected, particularly by Fusarium species that decrease yields as well as grain quality and safety, due to contamination with harmful mycotoxins, most importantly the trichothecene deoxynivalenol (DON). Climate change increases the incidence of unexpected disease outbreaks, and management by fungicides is of limited success and unsustainable, making Fusarium resistance an important breeding target. The CerealGSTs project aims to identify novel routes for detoxification of Fusarium mycotoxins in oat, with a main focus on GST-mediated reactions. We will identify the detoxification pathways and the involved genes and enzymes using a combination of metabolomics, transcriptomics and enzyme characterization in vitro and in planta. The successful candidate will drive the in depth characterization of enzymes in the oat-Fusarium interaction, using heterologous expression systems, purification and assays of enzymes, supported by targeted and untargeted LC-MS analyses to identify substrates and products from the in vitro assays and in the plant-pathogen interaction.The ideal candidate has a PhD in plant biochemistry or similar fields and extensive experience in heterologous expression of plant enzymes, enzymology and in vitro enzyme characterization, and relevant experiences with XC-MS analyses. Additional experience and qualifications within other ‘omics technologies, plant molecular biology, detoxification enzymes, general plant work and/or plant pathology is also an advantage. Furthermore, we are looking for a person with the following skills and mindset:

• Enthusiasm for collaboration and good interpersonal and communication skills
• Experience with supervision and mentoring of students
• Curiosity towards biological questions and an open mindset for knowledge sharing
• Ability to work independently, manage and carry through your research project
• Strong scientific writing and publication record
• Ability to critically review research results generated as part of the project
• Positive attitude for engaging in Departmental and Section activities including lab duties, teaching and dissemination of your research

Inquiries about the position can be made to Associate Professor Nanna Bjarnholt, nnb@plen.ku.dk.The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.Terms of employmentThe position is covered by the Memorandum on Job Structure for Academic Staff.Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.Negotiation for salary supplement is possible.The application, in English, must be submitted electronically by clicking APPLY NOW below.Please include with your application

• Cover letter
• Curriculum vitae
• Diplomas (Master and PhD degree or equivalent)
• The outline of a possible research plan for the project
• Complete publication list
• Separate reprints of 3 particularly relevant papers

The deadline for applications is 7 March 2025, 23:59 GMT +1.After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.You can read about the recruitment process at .Interviews will be held in March.Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

Expected salary:

Location: København

Job date: Sun, 23 Feb 2025 08:01:05 GMT

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